Can I create CRM workflows using .NET 4?
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CRM 4 is built for .NET 2.0 / 3.0. Thus, the only way to work with .NET 4.0 and CRM 4.0 is to isolate them in their own process. CRM 5.0 will use .NET 4.0, so you can use it with the next version of CRM.
With some tweeks, you should be able to partially work with .NET 4.0, but if it's similar to CRM 3.0 and .NET 2.0, the other parts will be broken without a workaround.
More information can be found on the Ascentium blog at http://xrm.ascentium.com/blog/crm/Post834.aspx
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